It seems to me that quantum uncertainties, if projected into the physical world in general, rule out absolute "perpetual motion". Do internal stresses in somethiing not perfectly elastic, ***tides*** eventually slow the rotation of our planet Earth, spinning "frictionless" in a vacuum?

Isaac Newton didn't know about that when he "discovered"/rediscovered the "laws" of motion, did he?

An intelligent designer, though, could get a fairly close approximation of "perpetual motion". You could draw energy out of the electromagnetic spectrum with a semiconductor device, possibly even in the DNA spiral, and run something indefinitely, against the apparent friction and decaying tendencies. Meanwhile, we don't know for sure if the universe will constantly expand, or contract. What seems to be sure, equilibrium is, intuitively to me, always temporary.