"Lack of exercise, over a long period of time is currently thought to be the primary, or preponderant, cause of sarcopenia.[1] Just as fitness is cumulative, so sarcopenia is also cumulative, reflecting years of chronic inactivity or lack of access to exercise. Not only muscle but the entire musculoskeletal system, of muscle, neuromuscular responsiveness, endocrine function, vasocapillary access, tendon, joint, ligament, and bone, depends on regular and lifelong exercise to maintain integrity. The slow attenuation, atrophy, or loss of muscle tissue that medical professionals sometimes describe as sarcopenia (literally, "flesh loss') is currently thought to be the result of cumulative loss of musculoskeletal strength and mass associated with chronic absence of exercise of sufficient intensity or volume."