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Two Part Invention by Bach Performed by Remi
Human Cloning |
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Dolly, the first viable clone of a sheep, was created in the following manner.
A developing egg cell from the ovary of a sheep was enucleated (had its nucleus removed) and fused with a somatic mammary cell from
another adult sheep. This fusion was accomplished by placing the two cells close to each other and passing an electric current through
them. The resulting cell, actually a zygote, was then treated in a way similar to that used with in vitro fertilization.
(In vitro fertilization is the method of creating "test tube babies".) After the modified cell had divided several times,
the resulting germinal stage embryo was implanted in a
surrogate mother sheep and was allowed to gestate normally, resulting in Dolly. Dolly was thus an identical twin to the sheep
whose mammary cell had fused with the developing egg cell (oöcyte). It was not quite as nearly identical as a naturally occurring twin,
however, because some of the mitochondrial DNA from the oöcyte was present in the resulting zygote. The mitochondria are small structures
inside the cell which may have at one time in evolution been free living organisms in their own right. In animal cells, however, they
have evolved to provide energy needed by the cell and may play other roles as well, possibly even storing information in neurons and
thus playing a role in memory. Please note that there is no particular significance attached to the use of a mammary cell. Cells from
many different parts of the body can be used in cloning.
The successful cloning of a sheep aroused much interest
because of the obvious implication that humans might also be cloned in a similar fashion. Many different animals have been cloned now
including mice and monkeys, and it appears quite certain that humans can be cloned. Indeed, human clones may already have been
produced. Any such cloning procedure would probably not be advertised because of the strident objections that have been raised
against the procedure.
We believe that there should be no laws that ban research into, or production of, human clones.
A human clone would be like an identical twin to the adult whose cell was used to create it, but it would of course be much younger. It
would be like a delayed twin. The Catholic Church has declared that cloning humans is "repugnant". What is so repugnant about it? Is it
repugnant to have an identical twin brother or sister? If not, what is the difference? Well, if you have an identical twin it happened by
accident. No one made it happen. So how is it perfectly fine and acceptable for something to happen by accident and "repugnant" to have
it happen on purpose?
Banning outright even fundamental research for cloning humans, as our U.S. Congress has naively proposed,
would be like banning automobiles because they can kill people. There are dangers of course, but like any other technological discovery
cloning can be subjected to intelligent controls. An excellent reason for keeping human cloning legal is that a law banning it would be
unenforceable. Cloning will take place whether such a law is passed or not. If cloning is banned in the United States, it will be done in
other countries. In the unlikely event that a worldwide ban were enacted it would be easy to do the cloning illegally in the countries
that pretend they have the means to control each of their citizens, or even legally aboard ships in international
waters. Having the ability to clone people, together with the associated technologies of genetics, has such immense potential advantages
that any country which might ban this technology would be resigning itself to second class citizenship in the scientific world. If the
United States fails to lead, many other nations have enough knowledge and resources to develop this new resource.
Cloning adds a burden of responsibility. Remember all the stories about the genie in the bottle? We
have a new genie and we must think of the right wishes. Trying to put the genie back in the bottle is not an intelligent course of action.
It is also impossible.
Those who find human cloning abhorrent argue that we are "playing God" like
Mickey Mouse in "The Sorceror's Apprentice." We find this
a most curious if not outright ridiculous notion.
When I was a child, my elders warned me not to
"tamper" with things such as old clocks that no longer ran.
They didn't notice that I could disassemble the clock, clean
it, reassemble it, and it would run! The Royal Navy discouraged innovation in the building of ships in
the early 1800's, one result being that French ships were often of superior construction.
My favorite historical novelist, Patrick O'Brian, tells us in his Aubrey-Maturin novels that there
was an aphorism in the Spanish Navy that said, "May nothing new arise!" Ever since the
discovery of fire and the wheel there have been those who predicted dire consequences from new discoveries. The Greeks
thought that if their ships sailed too far from shore, the gods would be angered and would punish them
with storms. It was considered "hubris" to go too far out to sea! Surely we have learned by now that
although new knowledge always has risks, the benefits are worth it. The idea of Pandora's box, which
if we open it will release the Furies upon us is an old one, and many "furies" have indeed been released.
But the lesson of history is that we are better off to make discoveries and then cope with them.
The atomic bomb is sometimes mentioned here.
But the harm done at Hiroshima and Nagasiki
is insignificant when compared to the benefits of an early end to the war in the Pacific
and all the technologies that have flowed
from our understanding of atomic energy.
People who oppose new ideas often put the word
"progress" in quotes as though real progress is a delusion. But the same people
drive cars, fly in jet planes, use telephones, surf the Net, watch TV, live in air conditioned houses, and cook with
microwave ovens. To be consistent, people opposed to scientific progress should join the Amish!
In the short term, cloning will provide unique insights into the
role of the environment in the development of human abilities and personality. It will make it possible, in a very real sense, for parents
who have lost a child to bring him or her back to life. And what a tribute it would be to a person to be selected for cloning! It would be
like a request for an encore! And in the long term, cloning and other advances in genetics offer the option of having unusually happy,
healthy, friendly, intelligent, and creative people. These scientific advances are likely to turn out to be the most important in history.
We may one day control our evolution as a species, as Teilhard de Chardin predicted early in the last century. Such an outcome will eclipse
all previous progress in medicine and will offer the promise of eradicating hundreds of diseases and improving resistance to hundreds of
others. The ultimate benefit is probably unimaginable to most of us. Consider the information revolution for a moment. How many of us
foresaw the enormous and all pervading benefits which that revolution would bestow? Even Bill Gates once said that computers and telephones
didn't have anything to do with each other! This simply shows that it is very difficult to foresee the implications of new scientific
advances, even for someone actively engaged in those advances.
Until recently, farmers have been limited to
selective breeding to improve strains of cattle, sheep, grapes, or corn.
Genetic engineering has opened up a stunning variety of methods to
improve any plant or animal species.
Attention here will center on the human species.
The selective breeding of humans has been practiced
since the beginning of recorded history.
Noble classes or castes as well as religious, ethnic, and racial groups have attempted
to outlaw out-group mating in an effort to maintain some kind of supposed "purity"
and also to increase the numbers of the particular group.
No one should really suppose that the idea of improving the human species
is a new thing.
Now, the options for achieving improvement have made a gigantic leap forward.
We are no longer limited to the tedious process of selective breeding
which requires many generations to achieve observable results.
Techniques for modifying the genetic material within the gametes (sperm and
egg cells) have unveiled previously inconceivable opportunities. The possibilities are limitless,
although the research and development will take time and require
funding and public support (rather than fear and legal interference).
Recently genetic material from a jelly fish was inserted into cloned monkeys,
and some of them actually glowed in the dark!
Opponents of genetic
engineering are quick to point out that things can go wrong.
Even without genetic engineering things frequently go wrong.
Fetuses spontaneously abort because of a genetic defect.
In in vitro fertilization many of the fertilized ova or germinal stage
embryos have to be discarded because they begin to show evidence that all is not well.
(This is somewhat off the subject, but I wonder what
the people who want to make abortion illegal think about in vitro fertilization.
They might want to protest the discarding of defective
zygotes and embryos in in vitro fertilization labs!)
As
we learn more about the role of genes in personality, we may discover that
we can
prevent numerous kinds of criminality as well as personality types prone to depression
or violence. Objecting to such research
on the grounds that we might create a person who was too passive is unfair.
X-rays can cause
cancer, but we still use them because the benefits outweigh the liabilities.
The same holds true of genetic engineering.
Efforts have been made to get the United Nations
to pass a ban on human reproductive cloning. This is
a ridiculous measure.
It has been said that human cloning would be destructive to human dignity.
Those that feel that way can simply resolve not to clone themselves.
They should not try to prevent others from following their own concept of human dignity.
Others point to the fact that when animals are cloned that some of
the clones have birth defects.
Someone said that if humans are cloned "something could go terribly wrong."
Well, we shouldn't fly airplanes.
Every time an airplane takes off something could go terribly wrong.
Automobiles should be banned too, because accidents happen.
Excessive worrying and hand-wringing offends human dignity.
Those with courage think of what can be gained.
An old term for genetic engineering is "eugenics". We have avoided that word because of its association
with the excessive zeal (based on ignorance) of the "social Darwinism" movement. To gain more background into the subject, and for
related links, click
here for some Encyclopedia Britannica articles on eugenics. Don't miss the excellent article on
Sir Francis Galton, an early genetic engineering proponent who influenced Charles Darwin. There is a current controversy regarding whether the federal government
should support (fund) research on stem cells obtained from human germinal stage embryos. These embryos are obtained from
infertility clinics which use the technique of in vitro fertilization. Couples who are infertile for a number of
different reasons may successfully have children using this method. The clinic obtains eggs and sperm cells from the potential
parents and then allows the sperm cells to fertilize a number of egg cells in the laboratory. (This is why the technique is
called "in vitro" which means "in glass".) Since there are a number of ways accidental failures can occur in this process,
a number of egg cells are fertilized in this way. And since inducing a pregnancy is not a sure thing, even with a
successfully fertilized egg cell, usually more than one attempt at implantation is made. When a pregnancy is successfully
brought about, a number of these small collections of cells are left over. While waiting for the pregnancy attempts these
specimens are kept frozen. The specimens are actually "germinal stage" embryos because they have not yet been implanted
in the uterus. Now a very young embryo contains some highly interesting cells known as "stem" cells. (Perhaps this
name was selected by analogy with plants in which branches and leaves can grow from a stem.) The reason these cells are so
important is that almost none of their genes have been "turned off". As an embryo develops and turns into a fetus, the cells
that make it up begin to specialize to form the various parts of the body. This is accomplished by deactivating certain genes.
An embryonic stem cell has the potential to become any kind of cell. It can become a liver cell, a brain cell, a bone cell,
a kidney cell, and so on for all the different kinds of cells that make up the human body. They are accordingly called
"pluripotent" cells because they have the power (potency) to become a plurality of different cells. Consider the zygote
for a moment. This is the fertilized egg cell. The zygote is "totipotent" because it can not only produce all the
different cells in the body it can also produce the cells necessary for implantation and the initiation of pregnancy. There
is a sort of heirarchy of cells which goes from the zygote, which is "totipotent", through the embryonic stem cells, which are
"pluripotent", to the somatic stem cells, which are "multipotent". In the adult body there are stem cells called somatic
stem cells which can turn
themselves into specialized cells in a particular context, but not everywhere. When you cut your finger there are stem
cells that turn into scar tissue skin cells and attach themselves to the damaged tissues to heal the cut. But these stem cells
can't replace liver cells that are lost because of dietary deficiencies or pancreatic cells in diabetics, for example.
So it is perfectly clear that we
need to make a special study of these embryonic stem cells. They give us the best hope of solving many medical problems.
And this hope is not far fetched or merely visionary. Much progress has already been made, and the technologies which
will be needed to capitalize on future discoveries are well developed. (Go
here for more detailed information.) We welcome rational and invigorating discussion on these suggestions for human cloning and genetic
engineering!
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