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Human Cloning
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 Humans are on the threshold of taking control of their own evolution! 
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This page was last modified on Friday, 15-Jan-2010 06:49:26 MST


The First Successful Clone of a Sheep

Who's Afraid of Human Cloning?

A Brief Overview of Genetic Engineering

Stem Cell Research








The First Successful Clone of a Sheep

Baaaah!

     Dolly, the first viable clone of a sheep, was created in the following manner. A developing egg cell from the ovary of a sheep was enucleated (had its nucleus removed) and fused with a somatic mammary cell from another adult sheep. This fusion was accomplished by placing the two cells close to each other and passing an electric current through them. The resulting cell, actually a zygote, was then treated in a way similar to that used with in vitro fertilization. (In vitro fertilization is the method of creating "test tube babies".) After the modified cell had divided several times, the resulting germinal stage embryo was implanted in a surrogate mother sheep and was allowed to gestate normally, resulting in Dolly. Dolly was thus an identical twin to the sheep whose mammary cell had fused with the developing egg cell (oöcyte). It was not quite as nearly identical as a naturally occurring twin, however, because some of the mitochondrial DNA from the oöcyte was present in the resulting zygote. The mitochondria are small structures inside the cell which may have at one time in evolution been free living organisms in their own right. In animal cells, however, they have evolved to provide energy needed by the cell and may play other roles as well, possibly even storing information in neurons and thus playing a role in memory. Please note that there is no particular significance attached to the use of a mammary cell. Cells from many different parts of the body can be used in cloning.

     The successful cloning of a sheep aroused much interest because of the obvious implication that humans might also be cloned in a similar fashion. Many different animals have been cloned now including mice and monkeys, and it appears quite certain that humans can be cloned. Indeed, human clones may already have been produced. Any such cloning procedure would probably not be advertised because of the strident objections that have been raised against the procedure.


Who's Afraid of Human Cloning?

     We believe that there should be no laws that ban research into, or production of, human clones. A human clone would be like an identical twin to the adult whose cell was used to create it, but it would of course be much younger. It would be like a delayed twin. The Catholic Church has declared that cloning humans is "repugnant". What is so repugnant about it? Is it repugnant to have an identical twin brother or sister? If not, what is the difference? Well, if you have an identical twin it happened by accident. No one made it happen. So how is it perfectly fine and acceptable for something to happen by accident and "repugnant" to have it happen on purpose?

     Banning outright even fundamental research for cloning humans, as our U.S. Congress has naively proposed, would be like banning automobiles because they can kill people. There are dangers of course, but like any other technological discovery cloning can be subjected to intelligent controls. An excellent reason for keeping human cloning legal is that a law banning it would be unenforceable. Cloning will take place whether such a law is passed or not. If cloning is banned in the United States, it will be done in other countries. In the unlikely event that a worldwide ban were enacted it would be easy to do the cloning illegally in the countries that pretend they have the means to control each of their citizens, or even legally aboard ships in international waters. Having the ability to clone people, together with the associated technologies of genetics, has such immense potential advantages that any country which might ban this technology would be resigning itself to second class citizenship in the scientific world. If the United States fails to lead, many other nations have enough knowledge and resources to develop this new resource.

     The U.S. Congress's attempts to ban cloning can be compared to an ostrich burying its head in the sand at the approach of a tiger, thinking that if it cannot see the tiger, the tiger is not there. We know the tiger is there.   and he will pounce on you if you turn your back on him

     Cloning adds a burden of responsibility. Remember all the stories about the genie in the bottle? We have a new genie and we must think of the right wishes. Trying to put the genie back in the bottle is not an intelligent course of action. It is also impossible.

     Those who find human cloning abhorrent argue that we are "playing God" like Mickey Mouse in "The Sorceror's Apprentice." We find this a most curious if not outright ridiculous notion. When I was a child, my elders warned me not to "tamper" with things such as old clocks that no longer ran. They didn't notice that I could disassemble the clock, clean it, reassemble it, and it would run! The Royal Navy discouraged innovation in the building of ships in the early 1800's, one result being that French ships were often of superior construction.

     My favorite historical novelist, Patrick O'Brian, tells us in his Aubrey-Maturin novels that there was an aphorism in the Spanish Navy that said, "May nothing new arise!" Ever since the discovery of fire and the wheel there have been those who predicted dire consequences from new discoveries. The Greeks thought that if their ships sailed too far from shore, the gods would be angered and would punish them with storms. It was considered "hubris" to go too far out to sea! Surely we have learned by now that although new knowledge always has risks, the benefits are worth it. The idea of Pandora's box, which if we open it will release the Furies upon us is an old one, and many "furies" have indeed been released. But the lesson of history is that we are better off to make discoveries and then cope with them. The atomic bomb is sometimes mentioned here. But the harm done at Hiroshima and Nagasiki is insignificant when compared to the benefits of an early end to the war in the Pacific and all the technologies that have flowed from our understanding of atomic energy. People who oppose new ideas often put the word "progress" in quotes as though real progress is a delusion. But the same people drive cars, fly in jet planes, use telephones, surf the Net, watch TV, live in air conditioned houses, and cook with microwave ovens. To be consistent, people opposed to scientific progress should join the Amish!

Religion stops a thinking mind    Another belief expressed by people from traditional religious backgrounds is that our bodies are not our own but "belong to God". There are, indeed, passages in "scripture" that can be interpreted to imply as much. What a ridiculous idea! How preposterous!
Believing such a thing encourages dereliction of responsibility for ourselves and our health. Perhaps using penicillin is playing God, and eating a balanced diet and having an exercise program is usurping God's ownership of our bodies.

     In the short term, cloning will provide unique insights into the role of the environment in the development of human abilities and personality. It will make it possible, in a very real sense, for parents who have lost a child to bring him or her back to life. And what a tribute it would be to a person to be selected for cloning! It would be like a request for an encore! And in the long term, cloning and other advances in genetics offer the option of having unusually happy, healthy, friendly, intelligent, and creative people. These scientific advances are likely to turn out to be the most important in history. We may one day control our evolution as a species, as Teilhard de Chardin predicted early in the last century. Such an outcome will eclipse all previous progress in medicine and will offer the promise of eradicating hundreds of diseases and improving resistance to hundreds of others. The ultimate benefit is probably unimaginable to most of us. Consider the information revolution for a moment. How many of us foresaw the enormous and all pervading benefits which that revolution would bestow? Even Bill Gates once said that computers and telephones didn't have anything to do with each other! This simply shows that it is very difficult to foresee the implications of new scientific advances, even for someone actively engaged in those advances.



A Brief Overview of Genetic Engineering

    Until recently, farmers have been limited to selective breeding to improve strains of cattle, sheep, grapes, or corn. Genetic engineering has opened up a stunning variety of methods to improve any plant or animal species. Attention here will center on the human species. The selective breeding of humans has been practiced since the beginning of recorded history. Noble classes or castes as well as religious, ethnic, and racial groups have attempted to outlaw out-group mating in an effort to maintain some kind of supposed "purity" and also to increase the numbers of the particular group. No one should really suppose that the idea of improving the human species is a new thing. Now, the options for achieving improvement have made a gigantic leap forward. We are no longer limited to the tedious process of selective breeding which requires many generations to achieve observable results. Techniques for modifying the genetic material within the gametes (sperm and egg cells) have unveiled previously inconceivable opportunities.
Genes associated with genetically caused diseases have been identified, and it may soon be possible to replace those genes with others in the zygote making the resulting child free of the defect. Also, genetic material can be imported from other species of animals to produce humans having, for example, the chimpanzee's resistance to HIV, or humans who make their own vitamin C as do the Pandas. Science fiction stories in which humans have evolved wings may be a little on the fanciful side, but perhaps teenagers with feathers would add spice to life!
  Let's order some wings!
"Gemini" a painting by Kagaya

     The possibilities are limitless, although the research and development will take time and require funding and public support (rather than fear and legal interference). Recently genetic material from a jelly fish was inserted into cloned monkeys, and some of them actually glowed in the dark!

     Opponents of genetic engineering are quick to point out that things can go wrong. Even without genetic engineering things frequently go wrong. Fetuses spontaneously abort because of a genetic defect. In in vitro fertilization many of the fertilized ova or germinal stage embryos have to be discarded because they begin to show evidence that all is not well. (This is somewhat off the subject, but I wonder what the people who want to make abortion illegal think about in vitro fertilization. They might want to protest the discarding of defective zygotes and embryos in in vitro fertilization labs!)

     As we learn more about the role of genes in personality, we may discover that we can prevent numerous kinds of criminality as well as personality types prone to depression or violence. Objecting to such research on the grounds that we might create a person who was too passive is unfair. X-rays can cause cancer, but we still use them because the benefits outweigh the liabilities. The same holds true of genetic engineering.

Eugenics revisited?    A common fear is that the government will force genetic engineering on people. We propose nothing more than a program of voluntary genetic counselling. The aim would be to help couples who want to be parents to have the very best child their genes can provide. Who would be opposed to that? Everyone has genes which are more or less undesirable in various ways. Having the ability to screen these genes out is a clear advantage. You could also import genes from a gene bank that would give your child "perfect pitch" or drawing ability, or a complexion free of acne, or athletic ability, or mathematical ability, or . . . the list will no doubt be a long one indeed when we know a great deal more. A successful voluntary program in time would be so obviously advantageous that everyone would want to participate in it!

    Programs like the above are often derided as "eugenics" and then dismissed on the grounds that the Nazis practiced eugenics. Many people also avoid Wagnerian opera because Hitler liked it.  That is not a rational reason to deprive yourself of Wagner's marvelous music.    In the trash can of history
The Nazis conducted very bad research on live human subjects based on their racial theories.  But that doesn't mean that all research having to do with the genetic makeup of humans is doomed to be as disgusting and incompetent as that research was.

     Efforts have been made to get the United Nations to pass a ban on human reproductive cloning.  This is a ridiculous measure.  It has been said that human cloning would be destructive to human dignity.  Those that feel that way can simply resolve not to clone themselves.  They should not try to prevent others from following their own concept of human dignity.  Others point to the fact that when animals are cloned that some of the clones have birth defects.  Someone said that if humans are cloned "something could go terribly wrong."   Well, we shouldn't fly airplanes.  Every time an airplane takes off something could go terribly wrong.  Automobiles should be banned too, because accidents happen.  Excessive worrying and hand-wringing offends human dignity.  Those with courage think of what can be gained.

Dr. Antinori   
Dr. Antinori
Drs. Panos Zavos and Severino Antinori announced in early August, 2001 that they would begin actual human cloning within a matter of weeks. They had over two hundred couples who would provide biological material.  They said that the cloning would be attempted in "two secret locations" and that if efforts by governments were made to stop the experiment, they would move into international waters. There will always be enormous pressures to go ahead and produce human clones in spite of any laws against it.  Performing the task in international waters is one way it could be done, but if covert, it could be done anywhere, much as illegal drugs are manufactured in the United States despite the senseless drug war.
Making laws against human cloning offers no benefits, only harm.  Such laws foster a situation in which cloning procedures will be attempted by scientists before adequate research paves the way for safe and effective methods.  The very horrors feared by the U.S. Congress will, due to their interference, become a reality.

     An old term for genetic engineering is "eugenics". We have avoided that word because of its association with the excessive zeal (based on ignorance) of the "social Darwinism" movement. To gain more background into the subject, and for related links, click here for some Encyclopedia Britannica articles on eugenics. Don't miss the excellent article on Sir Francis Galton, an early genetic engineering proponent who influenced Charles Darwin.


Stem Cell Research

     There is a current controversy regarding whether the federal government should support (fund) research on stem cells obtained from human germinal stage embryos.  These embryos are obtained from infertility clinics which use the technique of in vitro fertilization.  Couples who are infertile for a number of different reasons may successfully have children using this method.  The clinic obtains eggs and sperm cells from the potential parents and then allows the sperm cells to fertilize a number of egg cells in the laboratory.  (This is why the technique is called "in vitro" which means "in glass".)  Since there are a number of ways accidental failures can occur in this process, a number of egg cells are fertilized in this way.  And since inducing a pregnancy is not a sure thing, even with a successfully fertilized egg cell, usually more than one attempt at implantation is made.  When a pregnancy is successfully brought about, a number of these small collections of cells are left over.  While waiting for the pregnancy attempts these specimens are kept frozen.  The specimens are actually "germinal stage" embryos because they have not yet been implanted in the uterus.  Now a very young embryo contains some highly interesting cells known as "stem" cells.  (Perhaps this name was selected by analogy with plants in which branches and leaves can grow from a stem.)  The reason these cells are so important is that almost none of their genes have been "turned off".  As an embryo develops and turns into a fetus, the cells that make it up begin to specialize to form the various parts of the body.  This is accomplished by deactivating certain genes. An embryonic stem cell has the potential to become any kind of cell.  It can become a liver cell, a brain cell, a bone cell, a kidney cell, and so on for all the different kinds of cells that make up the human body.  They are accordingly called "pluripotent" cells because they have the power (potency) to become a plurality of different cells.  Consider the zygote for a moment.  This is the fertilized egg cell.  The zygote is "totipotent" because it can not only produce all the different cells in the body it can also produce the cells necessary for implantation and the initiation of pregnancy.  There is a sort of heirarchy of cells which goes from the zygote, which is "totipotent", through the embryonic stem cells, which are "pluripotent", to the somatic stem cells, which are "multipotent".  In the adult body there are stem cells called somatic stem cells which can turn themselves into specialized cells in a particular context, but not everywhere.  When you cut your finger there are stem cells that turn into scar tissue skin cells and attach themselves to the damaged tissues to heal the cut.  But these stem cells can't replace liver cells that are lost because of dietary deficiencies or pancreatic cells in diabetics, for example.   So it is perfectly clear that we need to make a special study of these embryonic stem cells.  They give us the best hope of solving many medical problems.   And this hope is not far fetched or merely visionary.  Much progress has already been made, and the technologies which will be needed to capitalize on future discoveries are well developed.  (Go here for more detailed information.)

So why is there objection to funding this research?  Before the stem cells are extracted from one of these embryos, it could potentially be implanted into a human female and could potentially develop into a fetus.  So the objections are similar to those against abortion.  Extracting those cells is, in one view, the same as killing a human being.  So according to some, the research scientists who are giving us such marvelous techniques for curing disease are now to share the epithet "baby killer" with those in family planning clinics who terminate pregnancies.

It is frequently said that the position of the Pope is consistent.  It is consistent because it opposes the termination of human life at any stage.  A person who favors permitting abortion but who wants to abolish the death penalty is inconsistent in that he is willing to allow killing at one stage of life but not at another. Likewise someone who opposes allowing abortion but favors permitting the death penalty is inconsistent for the same reason but in the opposite sense.  And the issue of when if ever euthanasia is an option is also a part of this problem.  Sometimes people try to use the idea of "when life begins" as a method of achieving consistency.  If you can show somehow that life hasn't begun at fertilization then you can permit abortion and prohibit capital punishment and still be consistent.  You can't kill something that isn't alive!  But life doesn't begin at any particular place.  As is pointed out in the Abortion Position Statement, the ovum (egg cell) is alive, the sperm cell is alive, the zygote is alive, the embryo is alive...there is no place where life begins because it never ends.  The Truth Tree's position is to permit abortion but to prohibit capital punishment.  This position achieves consistency by focusing not merely on the question of "is it alive?" or "is it dead?", but on a particular kind of value which I propose to call "noetic value".   Teilhard de Chardin divided the Universe into three "spheres": the geosphere, the biosphere, and the noösphere.   The geosphere is the world of nonliving physical things from hydrogen atoms to galaxies.  The biosphere is the world of fungi, plants, and animals on our planet and possibly elsewhere.  The noösphere is the world of consciousness.   It is in the noösphere that everything human takes place.  It seems highly plausible that many animals share in the noösphere with us to varying degrees, but humans are noticeably more noetic than any other species on our planet.   It is in the noösphere that speech, literature, art, science, theology, philosophy, poetry, and what we ordinarily call human life with its thinking and feeling take place.  It is the cluster of events which take place in the noösphere that we treasure most highly.  If we suffer from appendicitis we don't hesitate to snip off the living cells of the appendix to save the life of the whole person.  We value the noetic over the merely biological. This is a much more difficult position because the assessment of noetic value is perhaps not susceptible to precise and unambiguous definition.   But failing to face up to inevitable difficulty of this kind is the coward's way out.  It is much easier to take a simple rule such as "Thou shalt not kill" and try to make it fit every case than to formulate the terms and the equations that medical people in emergency rooms, operating rooms, and on battle fields frequently have to come to terms with.  They can tell you that some of the decisions they are forced to make are difficult indeed.  So what about this idea of "noetic value"? Is it something that occurs at a specific point in development?  Unfortunately not.  But I submit that neither does "the crack of dawn".  When is it actually Sunday?  At midnight Saturday night?  When it is light enough to read a newspaper?  When the upper edge of the Sun first appears?  We frequently make artificial boundaries superimposed on an underlying uninterrupted continuum.  The mere use of language to talk about the world makes artificial boundaries, and we have to use intelligence and insight to avoid making a hash of things.

The introduction of this philosophical basis for making value decisions enables us to be consistent in our attitudes toward stem cell research, in vitro fertilization, cloning, sperm banks, eugenics, genetic counselling, abortion, capital punishment, animal rights, and euthanasia.  It helps to clarify the real issues in these debates which are currently so filled with outrage and self-righteous pontification.  

Sometimes a patient in a hospital is maintained on life support systems in spite of the fact that the patient's brain is no longer functioning.  Such a patient has lost noetic value, and there is no way to restore it.  It is encouraging to note that medical and legal groups have achieved some success in getting courts to recognize that withdrawing life support from a patient with a "flat EEG" (which means that the brain is no longer functioning) is not murder.  It is certainly the killing of a "human being", or perhaps to state it more clearly it is the killing of the merely biological part of the human being.  This kind of decision provides an excellent example which shows the importance and consistency of the idea of noetic value.

It is The Truth Tree's position that human embryonic stem cell research is of the greatest importance and should be funded.  The idea that support should be withheld because proponents of particular religious ideas want it withheld is abhorrent.  Consulting religious authorities on an issue of this kind is about as reasonable as consulting Aristotle on how to launch a satellite.  A germinal embryo of the kind from which stem cells are extracted has as little noetic value as an appendix.  And what is the proposed alternative to using these cells in research?  If funding is interrupted and the research has to be discontinued, these embryos will simply be destroyed. It is to be hoped that if the federal government decides to withdraw support from these research programs that support will be found elsewhere.

CAVEAT: I am not claiming any special competence for myself in this or any other position statement on The Truth Tree.  I am not pontificating.  I do not set myself up as an "authority".  I do not think anyone should adopt these ideas just because I have them.  The only good reason for adoption of any of the ideas that appear on The Truth Tree is that the best evidence and the most convincing rational arguments favor them.  If the thought occurs to you that I am presuming too much, the best course of action is to come up with cogent arguments against the positions expressed here.  Then in public forum we have some chance of seeing which varieties and ranges of the expressed positions have the most merit.  Anyone has a perfect right to disagree.  But, in a sense, a position that is unchallenged by any meaningful alternative can be viewed as having achieved victory by default!

     We welcome rational and invigorating discussion on these suggestions for human cloning and genetic engineering!


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